Research on the use of evidence in health policy, associated barriers and facilitators, implementation strategies and knowledge brokerage has advanced over the last two decades. Current findings show certain promising common patterns and factors. Despite the absence of a ‘one-size-fits-all’-conclusion, results provide a ‘toolbox’ of different strategies and methods that researchers, knowledge brokers and policymakers could select from and tailor to the setting and needs of the specific situation. Picking the right tools to aid evidence-informed decision-making on bold political choices will be challenging. Research at least supports the hope that these efforts will be rewarded.